All states have newborn screening (NBS) programs, but many practitioners are unaware of what disorders their state/territory screens for via NBS. Additionally, despite newborn screening having existed for 50 years, many parents are unaware of this life-saving health service. This course will enable the learner to describe a general overview of the history of newborn screening, discuss the expansion of newborn screening and testing methodologies, and understand the scope of newborn screening and the role of healthcare providers.